HPE ProLiant Compute ML350 Gen12 6505P 12c 1P 1x32GB-R 4LFF

Lifecycle

• Obsolete Date 31-07-2029

Specifications

• Memory type HPE DDR5 Smart Memory
• Expansion slots Up to 10[1] PCIe Gen5 and 2 OCP slots. Refer to the QuickSpecs for more detail.
• Processor name Intel® Xeon® 6505P (12 core, 2.20 GHz, 48 MB L3, 150W)
• Included memory 32 GB (1×32 GB, 6400 MT/s)
• Included drives 2x HPE 4TB SATA 6G Business Critical 7.2K LFF LP 1-year Warranty Multi Vendor HDD
• System fan features 3x Standard Fans
• Network controller Broadcom BCM5719 Ethernet 1Gb 4-port BASE-T OCP3 Adapter for HPE
• Security UEFI Secure Boot and Secure Start support. Intel® Software Guard Extensions (SGX) support. Immutable Silicon Root of Trust. TPM (Trusted Platform Module) 2.0 support. Front bezel key-lock feature, Intrusion Cable (Optional), Padlock slot and Kensington Lock slot support. For full security features refer to the QuickSpecs.
• Storage controller HPE MR408i-o Gen11 x8 Lanes 4GB Cache OCP SPDM Storage Controller
• Processor number 1 processor included
• Processor speed 2.20 GHz
• Processor cache 48 MB L3
• Processor core available 12 core
• Infrastructure management HPE iLO Standard with Intelligent Provisioning (embedded), HPE OneView Standard (requires download); HPE iLO Advanced, HPE OneView Advanced (require licenses), and HPE Compute Ops Management (optional subscription available). Refer to the iLO 7 User Guide
• Optical drive type Optional DVD-ROM or DVD-RW. Refer to the QuickSpecs for more detail.
• Form factor 4U Tower
• Warranty 3/3/3: Server Warranty includes three years of parts, three years of labor, and three years of on-site support coverage. Additional information regarding worldwide limited warranty and technical support is available at: https://support.hpe.com/hpesc/public/docDisplay?docId=sd00004309en_us. Additional HPE support and service coverage, to supplement the product warranty, is available. For more information, visit: https://www.hpe.com/support.
• Power supply type 2x HPE 1000W Flex Slot Titanium Hot Plug Power Supply Kit

Quickspecs

• QuickSpecs
• QuickSpecs (PDF)
• QuickSpecs
• QuickSpecs (HTML)

Overview

Are you looking for our most flexible and powerful tower server for your SMB and remote offices? The HPE ProLiant Compute ML350 Gen12 is a robust 2P tower server with optional rackable chassis for various environments, and delivers exceptional compute performance, security, reliability, and expandability. Powered by latest Intel® Xeon® 6700/6500 P-series processors (up to 86 P-cores per socket), up to 8 TB DDR5 6400 memory, the HPE ProLiant Compute ML350 Gen12 server fulfills a wide range of demanding workloads. The silicon root of trust anchors the server firmware to an HPE-exclusive ASIC, creating a fingerprint for the Intel® Xeon® 6700/6500 P-series processors that must be matched exactly before the server will boot. The HPE ProLiant Compute ML350 Gen12 server is an excellent choice for diverse workloads such as IT infrastructure, data management, VDI, and ERP/CRM. Scale and adapt to any environment with this server and accelerate your growing business.

What’s new

• Includes HPE Integrated Lights-Out 7 (iLO 7) server management software that enables you to securely configure, monitor, and update your HPE ProLiant Compute Gen12 servers seamlessly from anywhere
• Supports new NS204i-u V2 as hot-pluggable, high-availability, RAID1-protected M.2 NVMe boot option
• Supports NVIDIA® L4 24GB Accelerator.
• Powered by Intel® Xeon® 6700 and 6500 series with P-cores; up to 86 P-cores per socket (172 P-cores per server), 350W (TDP); increased memory bandwidth to 6400 MT/s[2], up to 8 TB DDR5 memory capacity
• Supports ultra-high SSD performance with NVMe x4 and EDSFF drive cages, and allowing mixed dual-mode LFF and tri-mode SFF drive cages as hybrid storage optimization solution
• Provides up to 24 NVMe drives with PCIe Gen5 x2 bandwidth to have maximum storage capacity with balanced performance solution

Features

HPE Services simplify all stages of the IT journey. Advisory and Transformation Services professionals understand your challenges and design an effective solution. Professional Services enable rapid deployment of solutions and Operational Services provide ongoing support.

Services provided under Operational Services include: HPE Flexible Capacity, HPE Datacenter Care, HPE Infrastructure Automation, HPE Campus Care, HPE Proactive Services and multi-vendor coverage.

Industry-leading Services and Ease of Deployment

HPE IT investment solutions help you transform into a digital business with IT economics that align with your business goals.

Benefit from real-time operational feedback on server performance plus recommendations for fine-tuning BIOS settings to customize for changing business needs.

Next-Level Security, Chip to Cloud

Harness major compute performance. The HPE ProLiant Compute ML350 Gen12 server is powered by Intel® Xeon® 6700P/6500P-series processors that support up to 86 P-cores (172 P-cores per server) at 350W TDP.

Enjoy advanced data transfer rates and higher network speeds from the PCIe Gen5 serial expansion bus, with up to 4 x16 PCIe Gen5 and 2 x16 OCP slots to improve I/O throughput and reduce latency.

Optimized Performance for your Workloads: Accelerated, Open, and Efficient

The HPE ProLiant Compute ML350 Gen12 server is an excellent choice for compute and data storage demanding workloads (AI, machine learning [ML], telco, DB analytics,) requiring high core count, GPU capabilities, and network and I/O bandwidth.

From silicon to software, from factory to cloud, and from generation to generation, HPE ProLiant Compute Gen12 is engineered with a fundamental security approach to defend against increasingly complex threats through an uncompromising commitment to constant security advancements.

Silicon root of trust from HPE, establishes a zero-trust security framework at the silicon level to ensure firmware integrity. Continuous protection detects compromised servers and prevents them from booting if malicious code is found. Edge servers are safeguarded with default IDevID certificates.

HPE ProLiant Compute servers provide automated recovery from a security event, including restoration of validated firmware, and facilitating recovery of operating system, application and data connections, providing the fastest path to bring a server back online and into normal operations.

Intel® Xeon® 6 processors add hardware- and software-assisted security features such as Intel® Software Guard Extensions (SGX) for application isolation and Trusted Domain Extensions (TDX) for VM Isolation, which help protect the server hardware foundation and safeguard data in memory.

HPE iLO 7 supports quantum-resistant (PQC) algorithms and signs HPE ProLiant Compute Gen12 firmware with algorithms approved by CNSA 2.0, which enhances resilience against potential future attacks by quantum computers.

The HPE ProLiant Compute ML350 Gen12 server comes with a complete set of HPE Services, delivering confidence, reducing risk, and helping customers realize agility and stability.

Intuitive Cloud Operating Experience: Simple, Self-service, and Automated

HPE ProLiant Compute ML350 Gen12 servers are engineered for your hybrid world. The new HPE ProLiant Compute Gen12 servers simplify the way you control your business’s compute—from edge to cloud—with a cloud operating experience.

Transform business operations and pivot your team from reactive to proactive with global visibility and insight through a self-service console.

Automate tasks for efficiency in deployment, instant scalability, and seamless, simplified support and lifecycle management reducing tasks and shortening maintenance windows.

These experiences are engineered and built into all HPE ProLiant Compute Gen12 servers, whether purchased as physical servers or consume as-a-service using GreenLake Flex Solutions as your compute and storage demands grow.

Utilize 32 DIMM slots for up to 8 TB DDR5 memory with increased memory bandwidth and performance.

Media

Optimized for more performance and efficiency with HPE ProLiant Compute

The HPE ProLiant Compute portfolio is optimized for performance, efficiency, and cost with tailored solutions to power workloads from VDI to AI.

Automated, AI-driven productivity with HPE ProLiant Compute

Boost IT productivity with new AI-driven insights from HPE Compute Ops Management, enabling operators to react quicker and gain greater control, from forecasting energy costs to managing a global server footprint.

Next Level Security with HPE ProLiant Compute

Protect against attack with multi-layer security with HPE ProLiant Compute. HPE iLO multi-layer silicon root of trust protects servers from manufacturing to end-of-life and compliance readiness for future quantum-computing attacks.

Compatible products

• HPE 800W Flex Slot Platinum Hot Plug Low Halogen Power Supply Kit
• Red Hat Resilient Storage 2 Sockets or 2 Guests 1 Year Subscription E-LTU
• HPE 1800W-2200W FS Ti Ht Plg PS Kit
• HPE 1TB SATA 6G Business Critical 7.2K LFF LP 1-year Warranty Multi Vendor HDD
• HPE 2TB SATA 6G Business Critical 7.2K LFF LP 1-year Warranty Multi Vendor HDD
• MS WS25 16C Std ROK EU SW
• HPE MR416I-P GEN11 SPDM STORAGE CNTLR
• Red Hat Enterprise Linux for SAP for Virtual Datacenters 5yr Subscription 24×7 Support E-LTU
• Microsoft Windows Server 2025 50 Users CAL WW LTU
• MS WS25 16C Std Add Lic WW SW
• HPE 8TB SATA 6G Business Critical 7.2K LFF LP 1-year Warranty 512e Multi Vendor HDD
• RHEL Svr 2 Sckt 4 Gst 5yr 24×7 E-LTU
• HPE 16TB SAS 12G Business Critical 7.2K LFF LP 1-year Warranty Helium 512e ISE Multi Vendor HDD
• HPE StoreEver LTO-8 Ultrium 30750 Internal Tape Drive
• Broadcom BCM57504 Ethernet 10/25Gb 4-port SFP28 Adapter for HPE
• HPE SN1610Q 32Gb 1-port Fibre Channel Host Bus Adapter
• HPE 8TB SAS 12G Business Critical 7.2K LFF LP 1-year Warranty 512e Multi Vendor HDD
• HPE C13 – C14 WW 250V 10Amp Flint Gray 2.0m Jumper Cord
• RH HA 2 Sckt/2 Gst 5yr E-LTU
• Red Hat Enterprise Linux for SAP for Virtual Datacenters 3yr Subscription 24×7 Support E-LTU
• RHEL Svr 2 Sckt 4 Gst 3yr 9×5 E-LTU
• Red Hat Enterprise Linux Server 2 Sockets or 2 Guests 3 Year Subscription 9×5 Support E-LTU
• MS WS25 5Usr CAL WW LTU
• HPE C13 – C14 WW 250V 10Amp 2.0m Jumper Cord
• RHEL Svr 2 Sckt 4 Gst 5yr 9×5 E-LTU
• Red Hat Enterprise Linux for SAP (Physical/Virtual Nodes) 5yr Subscription 24×7 Support E-LTU
• HPE BladeSystem c-Class Virtual Connect 1G SFP SX Transceiver
• Red Hat Enterprise Linux Server 2 Sockets 1 Guest 1 Year Subscription 9×5 Support E-LTU
• BCM 57414 10/25GbE 2p SFP28 Adptr
• RHEL Svr 2 Sckt 4 Gst 1yr 9×5 E-LTU
• RH RS 2 Sckt Unltd Gst 3yr E-LTU
• MS WS25 RDS 5USR CAL WW LTU
• Red Hat Enterprise Linux for SAP (Physical/Virtual Nodes) 5yr Subscription 9×5 Support E-LTU
• HPE 100Gb QSFP28 MPO SR4 100m Transceiver
• Microsoft Windows Server 2025 2-core Standard Additional License WW SW
• HPE ProLiant Compute ML350 Gen11/Gen12 Smart Storage Battery Cable Kit
• Red Hat Enterprise Linux Server 2 Sockets or 2 Guests 1 Year Subscription 9×5 Support E-LTU
• HPE 100GbE QSFP28 SR4 100m Transceiver
• HPE SN1610Q 32Gb 2-port Fibre Channel Host Bus Adapter
• MS WS25 4C Std Add Lic WW SW
• HPE MR408i-o Gen11 x8 Lanes 4GB Cache OCP SPDM Storage Controller
• Red Hat Enterprise Linux for Virtual Datacenters 2 Sockets 5 Year Subscription 24×7 Support E-LTU
• Broadcom BCM5719 Ethernet 1Gb 4-port BASE-T Adapter for HPE
• Red Hat Enterprise Linux for SAP (Physical/Virtual Nodes) 3yr Subscription 24×7 Support E-LTU
• Microsoft Windows Server 2025 1 Device CAL WW LTU
• Red Hat High Availability 2 Sockets or 2 Guests 1 Year Subscription E-LTU
• HPE BladeSystem c-Class 10Gb SFP+ SR Transceiver
• MS WS25 RDS 1Usr CAL WW LTU
• HPE iLO Advanced Electronic License with 3yr Support on iLO Licensed Features
• Red Hat High Availability 2 Sockets or 2 Guests 3 Year Subscription E-LTU
• HPE 12TB SATA 6G Business Critical 7.2K LFF LP 1-year Warranty Helium 512e Multi Vendor HDD
• RHEL Svr 2 Sckt 4 Gst 1yr 24×7 E-LTU
• MS WS25 1USR CAL WW LTU
• HPE 20TB SATA 7.2K LFF LP ISE MV HDD
• HPE 4TB SATA 6G Business Critical 7.2K LFF LP 1-year Warranty Multi Vendor HDD
• HPE Proliant DL/ML Startup Service
• RHEL Svr 2 Sckt 1 Gst 1yr 24×7 E-LTU
• HPE Proliant DL/ML Install Service
• HPE 9.5mm SATA DVD-RW Optical Drive
• HPE 1000W Flex Slot Titanium Hot Plug Power Supply Kit
• HPE Smart Array E208e-p SR Gen10 (8 External Lanes/No Cache) 12G SAS PCIe Plug-in Controller
• HPE 1600W Flex Slot Platinum Hot Plug Low Halogen Power Supply Kit
• Broadcom BCM5719 Ethernet 1Gb 4-port BASE-T OCP3 Adapter for HPE
• MLX MCX631102 10/25GBE 2P SFP28 ADPTR
• Red Hat Enterprise Linux for Virtual Datacenters 2 Sockets 5 Year Subscription 9×5 Support E-LTU
• HPE BladeSystem c-Class 10Gb SFP+ LR Transceiver
• HPE ML350 GEN11 SEC CPU FAN KIT
• Red Hat Enterprise Linux for Virtual Datacenters 2 Sockets 3 Year Subscription 24×7 Support E-LTU
• Red Hat Resilient Storage 2 Sockets or 2 Guests 3 Year Subscription E-LTU
• HPE 4TB SAS 12G Business Critical 7.2K LFF LP 1-year Warranty Multi Vendor HDD
• RHEL Svr 2 Sckt 4 Gst 3yr 24×7 E-LTU
• Red Hat Enterprise Linux Server 2 Sockets or 2 Guests 1 Year Subscription 24×7 Support E-LTU
• RH HA 2 Sckt Unltd Gst 1yr E-LTU
• Red Hat Enterprise Linux Server 2 Sockets or Guests 5 Year Subscription 9×5 Support E-LTU
• HPE 96W Smart Storage Lithium-ion Battery with 260mm Cable Kit
• HPE LTO-7 Ultrium 15000 Internal Tape Drive
• RH RS 2 Sckt Unltd Gst 1yr E-LTU
• HPE C13 – KSC- 8305 KR 250V 10Amp 1.83m Power Cord
• Red Hat Enterprise Linux for SAP for Virtual Datacenters 5yr Subscription 9×5 Support E-LTU
• HPE iLO Advanced 1-server License with 3yr Support on iLO Licensed Features
• Red Hat Enterprise Linux Server 2 Sockets or 2 Guests 3 Year Subscription 24×7 Support E-LTU
• HPE MR216i-p Gen11 x16 Lanes without Cache PCI SPDM Plug-in Storage Controller
• Red Hat Enterprise Linux for Virtual Datacenters 2 Sockets 1 Year Subscription 9×5 Support E-LTU
• RH HA 2 Sckt Unltd Gst 3yr E-LTU
• Microsoft Windows Server 2025 4-core Datacenter Additional License WW SW
• Red Hat Resilient Storage 2 Sockets Unlimited Guests 5yr Subscription E-LTU
• RH HA 2 Sckt Unltd Gst 5yr E-LTU
• HPE iLO Advanced 1-server License with 1yr Support on iLO Licensed Features
• Broadcom BCM57416 Ethernet 10Gb 2-port BASE-T OCP3 Adapter for HPE
• Red Hat Enterprise Linux for SAP (Physical/Virtual Nodes) 3yr Subscription 9×5 Support E-LTU
• Broadcom BCM57416 Ethernet 10Gb 2-port BASE-T Adapter for HPE
• HPE 16TB SATA 6G Business Critical 7.2K LFF LP 1-year Warranty Helium 512e ISE Multi Vendor HDD
• BCM 57412 10GBE 2P SFP+ OCP3 ADPTR
• HPE C13 – CEE-VII EU 250V 10Amp 1.83m Power Cord
• Broadcom BCM57412 Ethernet 10Gb 2-port SFP+ Adapter for HPE
• Microsoft Windows Server 2025 10 Users CAL WW LTU
• HPE StoreEver LTO-7 Ultrium 15000 TAA-compliant Internal Tape Drive
• Red Hat Enterprise Linux for SAP for Virtual Datacenters 3yr Subscription 9×5 Support E-LTU
• Red Hat Enterprise Linux for Virtual Datacenters 2 Sockets 1 Year Subscription 24×7 Support E-LTU
• HPE 1.83m 10A C13-UL Dom Pwr Cord
• RH RS 2 Sckt/2 Gst 5yr E-LTU
• HPE MR416i-o Gen11 x16 Lanes 8GB Cache OCP SPDM Storage Controller
• HPE 960GB SATA 6G Read Intensive LFF LPC Multi Vendor SSD
• HPE iLO Advanced Electronic License with 1yr Support on iLO Licensed Features
• HPE Smart Storage Hybrid Capacitor with 260mm Cable Kit
• HPE MR216i-o Gen11 SPDM Storage Cntlr
• HPE 25Gb SFP28 SR 100m Transceiver
• HPE 12TB SAS 12G Business Critical 7.2K LFF LP 1-year Warranty Helium 512e Multi Vendor HDD
• Red Hat Enterprise Linux for Virtual Datacenters 2 Sockets 3 Year Subscription 9×5 Support E-LTU
• HPE 9.5mm SATA DVD-ROM Jb Gen9 Kit

Documents

• HPE ProLiant Compute ML350 Gen12 QuickSpecs
• Enterprise server acceleration from edge to data center

[1] Tertiary riser kit to support Slot 9/10 with PCIe Gen5 will be available in Q2, 2025.

[2] The maximum memory speed is a function of the memory type, memory configuration, and processor model.